Electric Literature of 313339-92-3,Some common heterocyclic compound, 313339-92-3, name is 3,5-Dichloropyrazine-2-carbonitrile, molecular formula is C5HCl2N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
The (4-tert-butoxy-carbonyl-aminophenyl) boric acid pinacone ester (8.26g) is added to include the magnetic stirring rod and 3,5-di-chloro-pyrazine-2-carbonitrile (5.0g), 1,1′-bis(diphenylphosphino)ferrocene palladium dichloride (1.68g) and cesium carbonate (28.1g) in the reaction container, subsequently joined 100 ml dioxane and 10 ml of water, the mixture is heated under stirring to 100 C. 1h reaction mixture after cooling to the room temperature and with the saturated aqueous solution of sodium bicarbonate (100 ml) for quenching and EtOAc (3¡Á200 ml) extraction. The combined organic phase is dried with sodium sulfate, filtered and evaporation to obtain brown oily crude product, the fast by silica gel chromatography using EtOAc and heptane mixture of purification as an eluent. The obtained product is used methyl tert butyl ether recrystallization and in the vacuum drying to obtain light yellow solid [4 – (6-chloro-5-cyano-pyrazine-2-yl)-phenyl]-amino- formic acid tert-butyl ester. Yield: 6.92g (73%).
The synthetic route of 313339-92-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Sanofi; Nazare, M; HALLAND, N; SCHMIDT, F; WEISS, T; Dietz, U; Hofmeister, A; (76 pag.)CN103012407; (2016); B;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem