Adding a certain compound to certain chemical reactions, such as: 143591-61-1, name is 3-Bromo-8-chloroimidazo[1,2-a]pyrazine, belongs to Pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 143591-61-1, Formula: C6H3BrClN3
A 33% (w/v) ethanol solution of methylamine (5.4 mL,130.55 mmol)was added to a solution of 3-bromo-8-chloroimidazo[1,2-a]pyrazine (500 mg, 2.15 mmol) in ethanol in a microwaveadaptedvial. The reaction was submitted to microwave irradiationsduring 20 min at 140 C. The solvent was removed underreduced pressure. The crude mixture was dissolved in ethyl acetateand successively washed with saturated aqueous chloride ammonium,distilled water and finally brine. The organic phase was driedon sodium sulphate, filtered and concentrated under reducedpressure. The compound is obtained as a white solid (92% yield). C7H7BrN4. Mw: 227.06 g/mol. Mp 145-146 C. 1H-RMN delta (ppm,400 MHz, DMSO-d6) 2.94 (d, 3H, NHCH3, J 6 Hz), 7.42 (d, 1H, CH 6,J 8 Hz), 7.52 (d, 1H, CH 7, J 8 Hz), 7.65 (m, 2H, NH, CH 2). 13CRMNdelta (ppm, 100 MHz, DMSO-d6) 22.77 (NHCH3), 97.83 (Cq 1),107.34 (CH 7),130.04 (CH 6),132.10 (CH 2),133.81 (Cq 3′),150.72 (Cq4). MS (ESI+ , QTof, m/z): 227.1 [M+H]+. HRMS calculated forC7H8BrN4 226.9932, found 226.9935.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Bromo-8-chloroimidazo[1,2-a]pyrazine, and friends who are interested can also refer to it.
Reference:
Article; Patinote, Cindy; Bou Karroum, Nour; Moarbess, Georges; Deleuze-Masquefa, Carine; Hadj-Kaddour, Kamel; Cuq, Pierre; Diab-Assaf, Mona; Kassab, Issam; Bonnet, Pierre-Antoine; European Journal of Medicinal Chemistry; vol. 138; (2017); p. 909 – 919;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem