Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 98-97-5, name is Pyrazine-2-carboxylic acid, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C5H4N2O2
2-Pyrazinecarboxylic acid (1.5g) in thionyl chloride (10ml_) was stirred at 110C undernitrogen for 2h. The solvent was evaporated under vacuum to give 2-pyrazinecarbonyl chloride as a dark purple solid(1.5g). (4-Bromo-2-fluorophenyl)(iodo)zinc in tetrahydrofuran (0.5M, 7.02mL) was added slowly to a stirred mixture of the acid chloride (1g) and tetrakis(triphenylphosphine)palladium(0) (4O6mg) in tetrahydrofuran (5mL) at room20 temperature under nitrogen then stirred for 2h. Aqueous ammonium chloride (1M, 10ml_) was added and the reaction mixture was partitioned between ethyl acetate and water. The organic phase was dried using a hydrophobic filter tube and concentrated under vacuum. The residue was purified by chromatography on a silica column eluting with a cyclohexane:ethyl acetate gradient to give the title compound as a yellow solid (215mg).25 LC-MS: Rt 2.83min.
According to the analysis of related databases, 98-97-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; SMITHKLINE BEECHAM CORPORATION; WO2005/73189; (2005); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem