In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 95-58-9 as follows. Computed Properties of C5H5ClN2
Example 1.1: 3-Methyl-pyrazin-2-ylamine (2) A mixture of 2-chloro-3-methylpyrazine (50 g; 389 mmol; 3B Pharmachem, Wuhan, China) and 300 g of gaseous NH3 dissolved in 200 ml of methanol are heated under stirring in an autoclave at 1600C for 8 hours. The reaction mixture is cooled, filtered, and the solvent is evaporated. The residue is stirred in cold acetone and treated for 10 minutes in an ultrasonic bath. After filtration, the solvent is evaporated to yield the title compound, which is used in the next step without further purification. HPLC: Rt = 0.36 min.Instrument : HP Series 1100 (G.08. CHR. S003) Solvent : acetonitrile – water (0.1% TFA) Gradient : 10% acetonitrile to 99% within 4 min lmin at 99%Flow: 2.0 ml / minDetection : 220/254 nm Column: Supelco Discovery C18, 50×4.6 mm, 5mum
According to the analysis of related databases, 95-58-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ONCALIS AG; CAPRARO, Hans-Georg; WO2010/83617; (2010); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem