Electric Literature of 143591-61-1, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 143591-61-1, name is 3-Bromo-8-chloroimidazo[1,2-a]pyrazine, This compound has unique chemical properties. The synthetic route is as follows.
In a 2000ml three-necked flask, with mechanical stirring, Ar gas protection. Join4.62 g of 3-bromo-8-chloroimidazo [1,2-a] pyrazine (molecular weight 231, 0.02 mol)5.6 g (molecular weight 254.2, 0.022 mol) of bis (pinacolato) diboron, 23.2 g (0.0044 mol) of Pd (dppf) Cl, 36 g (molecular weight 138,1,4-dioxane 500ml. Start mechanical stirring,After 3 times of evacuation under reduced pressure to maintain Ar gas protection,The reaction was monitored by TLC (thin layer chromatography)Until the complete disappearance of raw materials, reflux for 3 hours, the reaction was complete. Let cool, the reaction system divided into two layers, the organic layer was separated and evaporated to dryness to give 5.04g product, yield 90.2%.
The chemical industry reduces the impact on the environment during synthesis 3-Bromo-8-chloroimidazo[1,2-a]pyrazine. I believe this compound will play a more active role in future production and life.
Reference:
Patent; Beijing Dingcai Technology Co., Ltd.; Li Yinkui; Tang Jinming; Fan Hongtao; (34 pag.)CN104650116; (2017); B;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem