According to the analysis of related databases, 56423-63-3, the application of this compound in the production field has become more and more popular.
Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 56423-63-3, name is 2-Bromopyrazine, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of 2-Bromopyrazine
Example 269(S)-3-(4-chlorophenyl)-4-(3-(pyrazin-2-yloxy)phenyl)oxazolidin-2-one [00252] Reference: Org Lett 2003, 5(21), 3799. A small reaction tube fitted with a screw cap containing a septum is charged with (S)-3-(4-chlorophenyl)-4-(3-hydroxyphenyl)- oxazolidin-2-one (0.06 mmol), 2-bromopyrazine (0.076 mmol), CuI (0.04 mmol), NN- dimethylglycine (0.04 mmol), Cs2CO3 (0.13 mmol) and 1,4-dioxane (1 mL) is stirred at 1200C for 18h. The reaction mixture is then cooled to room temperature and filtered through a Whatman 0.42 muM filter and purified by preparative HPLC (C-18, 10-90 % ACnu/water (0.05 % TFA)). 1H nuMR (CDCl3, 400 MHz) delta 8.41 (d, J = 1.2 Hz, IH), 8.29 (d, J = 2.8 Hz, IH), 8.04 (dd, J = 2.8, 1.2 Hz, IH), 7.43 (t, J = 8.0 Hz, IH), 7.34 (d, J = 8.8 Hz, 2H), 7.24 (d, J = 8.2 Hz, 2H), 7.12-7.19 (m, 2H), 7.10 (s, IH), 5.37 (dd, 7 = 8.8, 6.0 Hz, IH), 4.80 (t, J = 8.8 Hz, IH), 4.26 (dd, 7 = 8.8, 6.0 Hz, IH); HPLC-MS calculated for Ci9Hi4ClN3O3 (M+H+) 368.1, found 368.1.
According to the analysis of related databases, 56423-63-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; IRM LLC; WO2008/76754; (2008); A2;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem