Related Products of 312736-50-8, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 312736-50-8 as follows.
solution of the compound (5.0 g, 13.3 mmol) obtained in Preparation Example 13.1 in MeCN (100 mL) was charged with POCl3 (6.76 mL, 72.3 mmol) and stirred at 80 for 4 h. After dilution with water, the mixture was extracted with EtOAc and washed with brine. The organic layer was dried over anhydrous magnesium sulfate, filtered, and concentrated under reduced pressure. The crude product was purified by column chromatography (20% n-hexane/EtOAc) to afford 3,5-dichloropyrazin-2-carbonitrile (2.94 g, 65%) as a solid.
According to the analysis of related databases, 312736-50-8, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ST Pharm Co. Ltd.; Kim, Kyeong Jin; Kim, Kwang Rok; Kim, Wook Il; Bang, Hyeong Tae; Yoon, Ji Hye; Im, Hwan Jeong; Ho, Cheong Nyeong; (50 pag.)KR2016/7347; (2016); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem