Electric Literature of 123-32-0, These common heterocyclic compound, 123-32-0, name is 2,5-Dimethylpyrazine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Preparation of 3,6-dimethyl-2- (4-trifluoromethyl) benzoyl pyrazine, comprising the steps of:(1) 2,5-dimethyl pyrazine take 0.2mmol, 3- trifluoromethylbenzoyl acid 0.4mmol, silver phosphate 0.02mmol, potassium persulfate 0.4mmol, 1.4mL was added dichloromethane, 0.6mL after the mixture was prepared with distilled water, and the mixture was placed in a reaction tube of 5mL was heated in an oil bath at 40 , the reaction 24h, cooled to room temperature to obtain a reaction solution;(2) The step (1) the resulting reaction mixture was directly concentrated to give a concentrate, the concentrate with ethyl acetate / petroleum ether = 1/2 (v / v) as the developing solvent, separation by thin layer chromatography to give 45mg target The product, in 43% yield.
The synthetic route of 123-32-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Henan Agricultural University; Wu Zhiyong; Zhao Mingqin; Li Yuan; (10 pag.)CN108101856; (2018); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem