Synthetic Route of 6966-01-4, These common heterocyclic compound, 6966-01-4, name is Methyl 3-amino-6-bromopyrazine-2-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
4- (PYRROLIDIN-1-YLSULFONYL) PHENYLBORONIC acid (0.33 g, 1.29 mmol), methyl 3-amino-6- BROMOPYRAZINE-2-CARBOXYLATE (0.25 g, 1.08 mmol; described in: H. Ellingson, J. Amer. Chem. Soc. 1949, 2798), K3PO3 (3 M, 1.1 mL, 3.2 mmol), and Pd (dppf) Cl2 (0.044 g, 54 JUMOL) were suspended in ethylene glycol dimethyl ether/water (1.5 : 0.5 mL) and heated in a microwave oven at 160 C for 10 min. The reaction was repeated 3 times. The combined product mixtures were evaporated with silica gel and the crude product was purified by chromatography on silica gel using a HEPTAN/ETHYLACETATE gradient as the eluent to give 0.96 g (82% yield) of the title compound: MS (ES) m/z 363 (M+1).
The synthetic route of 6966-01-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ASTRAZENECA AB; WO2004/55009; (2004); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem