Synthetic Route of 173253-42-4, These common heterocyclic compound, 173253-42-4, name is 2-Amino-5-bromo-6-chloropyrazine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of 5-bromo-6-chloropyrazin-2-amine (200 mg, 0.98 mmol, 1 eq.) in DMF (3 mL) was added 3-methyl pyrazole (312 mg, 3.8 mmol, 5.0 eq.) and Cs2CO3 (1.24 g, 3.8 mmol, 5.0 eq.). The reaction mixture was allowed to heat at 100 C. for 16 h. The progress of the reaction was monitored by TLC and LCMS The reaction mixture was diluted with water (30 mL) and extracted using ethyl acetate (2*50 mL). The separated organic layer was dried over sodium sulfate and concentrated under reduced pressure. The crude product was purified by normal phase column chromatography to afford the desired product (16 mg, 54%). LCMS: 309 [M+1]+. 1H NMR: (400 MHz, DMSO-d6) delta 9.35 (s, 1H), 8.06 (s, 1H), 7.96 (d, J=1.32 Hz, 1H), 7.90 (d, J=8.77 Hz, 1H), 7.81 (d, J=2.19 Hz, 1H), 7.13 (dd, J=1.75, 8.77 Hz, 1H), 6.98 (s, 2H), 6.23 (d, J=2.19 Hz, 1H), 2.08 (s, 3H).
Statistics shows that 2-Amino-5-bromo-6-chloropyrazine is playing an increasingly important role. we look forward to future research findings about 173253-42-4.
Reference:
Patent; GiraFpharma LLC; PHAM, Son Minh; CHEN, Jiyun; ANSARI, Amantullah; JADHAVAR, Pradeep S.; PATIL, Varshavekumar S.; KHAN, Farha; RAMACHANDRAN, Sreekanth A.; AGARWAL, Anil Kumar; CHAKRAVARTY, Sarvajit; (120 pag.)US2019/23666; (2019); A1;,
Pyrazine – Wikipedia,
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