Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 4858-85-9, name is 2,3-Dichloropyrazine, A new synthetic method of this compound is introduced below., Formula: C4H2Cl2N2
Under a nitrogen atmosphere,To a 25 mL test tube reactor was added substrate 2,3-dichloropyrazine 1 w (0.2 mmol,29.6 mg), KSAc(0.6mmol,68.4mg),DMC(1.0mmol,90mg),Pd(OAc)2(0.01mmol,2.3mg),PPh3 (0.02mmol,5.9mg),tBuOK(0.6mmol,69.2mg),and DMSO(2.0mL)..The reaction was heated to 120 C to carry out the reaction.After the TLC detection reaction was completed,The system was cooled to room temperature.The reaction was quenched with saturated aqueous ammonium chloride,And extracted with ethyl acetate (3 * 10 mL)The product was purified by column chromatography to give 28.2mg(82).of product 2w.
The synthetic route of 4858-85-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; East China Normal University; Jiang Xuefeng; Qiao Zongjun; (32 pag.)CN106866327; (2017); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem