Application of 41110-34-3, These common heterocyclic compound, 41110-34-3, name is Ethyl 5-methylpyrazine-2-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
The reaction was carried out, under nitrogen, in a 500 mL¡Á4 neck flask equipped with a mechanical stirrer, water condenser (with gas inlet), and a thermocouple. The reactor was charged with sodium tungstate dihydrate (1.35 g) and water (30 g). The mixture was stirred to dissolve the solid (10 minutes). Aqueous sulfuric acid (50%) was added bringing the pH down to about 3.5. Aqueous 35% hydrogen peroxide (22.36 g) was added and the solution was stirred for 15 minutes. 5-Methylpyrazinecarboxylic acid ethyl ester (27.27 g) was then added. The reaction mixture was warmed to 70 C. and then stirred for a total of 12 hours after which the reaction was checked by GC or GC/MS and was found to be complete. The resulting solution was concentrated under reduced pressure to yield a light yellow solid. The reaction mixture was cooled in an ice-bath for 3 hours. The product was collected by filtration and washed with ice water (25 g). Drying the solid at 60 C. under house vacuum yielded 20.57 g (69%) of the ester N-oxide.
The synthetic route of 41110-34-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ISP INVESTMENTS INC.; US2005/261312; (2005); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem