Some common heterocyclic compound, 98-97-5, name is Pyrazine-2-carboxylic acid, molecular formula is C5H4N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Application In Synthesis of Pyrazine-2-carboxylic acid
The title compound (1, Scheme 1) was prepared following the previously described procedure [23] via the reaction of pyrazine-2-carboxylic acid (A) (5 mmol) with thionyl chloride (7.5 mmol) in dry toluene to yield the corresponding acyl chloride (B), which was subsequently reacted with 3-iodo-4-methylaniline (5 mmol) in dry acetone with pyridine (5 mmol). The reaction was stirred at room temperature for1 hour, then poured into cold water. The crude product was collected, adsorbed on silica and purified by flash chromatography(silica, gradient elution ethyl-acetate in hexane0 e30%). The yield of chromatographically pure product was 84% oftheoretical yield related to acid (A). Elementary composition(CHON) of 1 was in the range of ¡À0.4% of calculated values and themelting point was consistent with literature (141e142 C) measured, 142e143 C from literature [23]. The FT-IR spectrum(Fig. 1) was recorded using KBr pellets on a DR/JASCO FT-IR 6300 spectrometer. The FT-Raman spectrum (Fig. 2) was obtained on a Bruker RFS 100/s, Germany. For excitation of the spectrum, the emission of Nd:YAG laser was used with an excitation wavelengthof 1064 nm, a maximal power 150 mW; measurement of solid sample.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 98-97-5, its application will become more common.
Reference:
Article; Ranjith; Al-Abdullah, Ebtehal S.; Al-Omary, Fatmah A.M.; El-Emam, Ali A.; Anto; Sheena, Mary Y.; Armakovi?, Stevan; Armakovi?, Sanja J.; Zitko, Jan; Dolezal, Martin; Van Alsenoy; Journal of Molecular Structure; vol. 1136; (2017); p. 14 – 24;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem