Adding a certain compound to certain chemical reactions, such as: 69214-33-1, name is 8-Chloroimidazo[1,2-a]pyrazine, belongs to Pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 69214-33-1, Quality Control of 8-Chloroimidazo[1,2-a]pyrazine
N-(4-(Imidazo[1,2-a]pyrazin-8-ylamino)phenyl)-4-methylbenzenesulfonamide (35) All glassware was dried and purged with Arprior to use. Pd2(dba)3(2.97 mg, 1 mol%), DavePhos (3.83 mg, 3 mol%) and NaOtBu (43.8 mg, 0.456 mmol) were dissolved in anhydroustoluene (3 mL). 8-Chloroimidazo[1,2-a]pyrazine (49.8 mg, 0.324 mmol) and N-(4-aminophenyl)-4-methylbenzenesulfonamide23 (106 mg, 0.389 mmol) were addedand the reaction was stirred under reflux, under Ar for 16 h. The reaction was cooled to RT and solventremoved in vacuo, before the residuewas taken up in CH2Cl2 (50 mL) and washed with H2O(3 x 30 mL) and brine (30 mL), dried (MgSO4), filtered andconcentrated in vacuo. Flash chromatography (applied in pet. ether;eluted 2:1 pet. ether/EtOAc) afforded the title compound as a brown solid (69.7mg, 0.184 mmol, 56%). Mpt: Decomposed before melting; Rf = 0.30 (3:1 EtOAc/pet. ether); IR (numax/cm-1,thin film): 3338, 3045, 1537, 1505; 1H NMR (600 MHz, CDCl3):deltaH = 2.37 (s, 3H, 21-H),6.88 (s, 1H, 15-H), 7.06 (d, J = 8.8 Hz, 2H, 13-H), 7.21 (d, J = 8.3Hz, 2H, 19-H), 7.45 (d, J = 4.6 Hz, 1H, 6-H), 7.56-7.57 (m, 3H, 2,3,5-H),7.63 (d, J = 8.3 Hz, 2H, 18-H), 7.76 (d, J = 8.8 Hz, 2H, 12-H),8.19 (s, 1H, 10-H); 13CNMR (150 MHz, CDCl3): deltaC = 21.7 (C-21), 111.9 (C-5),115.2 (C-3), 120.3 (C-12), 123.9 (C-13), 127.4 (C-18),128.4 (C-6), 129.7 (C-19), 131.1 (C-14), 131.9 (C-2),133.2 (C-9), 136.2 (C-17), 137.4 (C-11), 143.9 (C-20),146.0 (C-8); LRMS m/z (ES+):380 [M+H]+, 402 [M+Na]+; HRMS m/z (ES+): Found380.1168 [M+H]+; C19H18N5O2Srequires 380.1181.
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Reference:
Article; Sayer, James R.; Walldn, Karin; Pesnot, Thomas; Campbell, Frederick; Gane, Paul J.; Simone, Michela; Koss, Hans; Buelens, Floris; Boyle, Timothy P.; Selwood, David L.; Waksman, Gabriel; Tabor, Alethea B.; Bioorganic and Medicinal Chemistry; vol. 22; 22; (2014); p. 6459 – 6470;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem