117103-53-4, name is 2-Bromo-5-nitropyrazine, belongs to Pyrazines compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Computed Properties of C4H2BrN3O2
Step D: fert-butyl ethyl (5-nitropyrazin-2-yl)propanedioate: A suspension of NaH (60 %, 3.0 g, 75 mmol) in 100 mL of DMF was added tert-butyl ethyl propanedioate (14.1 g, 75 mmol) dropwise at 25 C. The mixture was stirred at 40 C for 30 minutes and 2-bromo-5-nitropyrazine (10.2 g, 50 mmol) in 50 mL of DMF was added dropwise. The resulting suspension was stirred at 50 C for 2 hours and diluted with 500 mL of EtOAc. The mixture was washed with water (100 mLx3), brine, dried over anhydrous Na2S04 and concentrated. The residue was purified by column chromatography (petrol ether : EtOAc = 5 : 1) to afford tert-butyl ethyl (5-nitropyrazin- 2-yl)propanedioate.
The synthetic route of 117103-53-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; MERCK SHARP & DOHME CORP.; DONG, Shuzhi; PASTERNAK, Alex; SUZUKI, Takao; GU, Xin; FU, Qinghong; JIANG, Jinlong; DING, Fa-Xiang; TANG, Haifeng; DEJESUS, Reynalda K.; WO2015/96035; (2015); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem