Reference of 109-08-0, A common heterocyclic compound, 109-08-0, name is 2-Methylpyrazine, molecular formula is C5H6N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Step C – Synthesis of mt 7-3 To a solution of 2-methylpyrazine (272 mg, 2.9 mmol) and HIVIPA (520 mg, 2.9 mmol) in THF (2.5 mL) was added LDA (1.6 mL, 3 mmol) at -78¡ãC dropwise. The mixture was allowed to stir at -78¡ãC for 30 minutes before a solution of mt 7-2 (600 mg, 2.45 mmol) in 2 mL of THF was added. The mixture was allowed to warm to room temperature for 3 hours before itwas quenched with 10 mL of saturated NH4C1 solution. The resulting mixture was extractedwith EtOAc (3 x 10 mL) and the combined organic washings were dried over sodlum sulfate,filtered and in vacuo. The resulting residue was purified using column chromatography (25percentEtOAc/ petroleum ether) to provide mt 7-3 (100 mg, 12percent). MS (ES): m/z (M+H) 339.
The synthetic route of 109-08-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; MERCK SHARP & DOHME CORP.; COBURN, Craig A.; MALETIC, Milana; SOLL, Richard; LI, Chunsing; LUO, Yunfu; QI, Zhiqi; WO2014/178; (2014); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem