Application of 109-08-0, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 109-08-0 as follows.
[00401] Intermediate 26: Synthesis of l-phenyl-2-(pyrazin-2-yl)ethanone[00402] To a mixture of diisopropyl-amine (1.29 g, 12.7 mmol) in anhydrous THF (10 mL) was added w-BuLi (2.5 M/L in hexane, 4.7 mL, 11.7 mmol) at -78C, after being stirred for 30 minutes, a solution of 2-methylpyrazine (1 g, 10.6 mmol) in THF (5 mL) was added, and the mixture was stirred at -78C for 30 minutes, a solution of methyl benzoate (1.4 g, 10.6 mmol) in THF (5 mL) was added, and the mixture was stirred at this temperature for 3 hours. When TLC indicated that the starting material was consumed, the reaction mixture was diluted with EtOAc, and the mixture was washed with water and brine, and concentrated. The residue was purified by column chromatography (PE:EtOAc=30: l) to give Intermediate 26 (700 mg, yield 33.3%).
According to the analysis of related databases, 109-08-0, the application of this compound in the production field has become more and more popular.
Reference:
Patent; N30 PHARMACEUTICALS, LLC; SUN, Xicheng; QIU, Jian; WO2011/38204; (2011); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem