In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1053656-22-6 as follows. Product Details of 1053656-22-6
To a solution of ethyl 7- (TERT-BUTOXYCARBONYL)- 5, 6,7, 8-tetrahydroimidazo [1, 2- A] PYRAZINE-2-CARBOXYLATE (4.28 g, 14.5 mmol) from Step A in 100 ML of carbon tetrachloride was added N-CHLOROSUCCINIMIDE (2.325 g, 17.4 mmol) and benzoyl peroxide (50 mg, 0.2 mmol) sequentially. The reaction was stirred at reflux for 1 h. The reaction mixture was cooled to 0 C, filtered, and the solid was washed with two 25-ML portions of dichloromethane. The solvent was concentrated in vacuo. Purification by flash chromatography on a BIOTAGE system (silica gel, gradient, 50 % ethyl acetate/hexane to 100 % ethyl acetate) afforded the title compound.
According to the analysis of related databases, 1053656-22-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; MERCK & CO., INC.; WO2004/58266; (2004); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem