In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 5049-61-6 as follows. Computed Properties of C4H5N3
5.1. 5-Bromo-2-pyrazinamine 28.2 g of N-bromosuccinimide (0.158 mol) are added portionwise, at 0 C., to a solution of 2-amino-pyrazine (15.0 g, 0.158 mol) in 900 ml of dichloromethane. After 3 hours, the reaction mixture is filtered through a sinter funnel, washed with saturated sodium carbonate (2*400 ml), water (400 ml) and brine (200 ml), dried over sodium sulphate, filtered and concentrated under reduced pressure. The residue obtained is purified on a column of silica eluted under pressure with a cyclohexane/ethyl acetate gradient (9/1) to (1/1). 18.0 g of 5-bromo-2-pyrazinamine are obtained in the form of a yellowish powder. Yield (%)=66; m.p. ( C.)=144
According to the analysis of related databases, 5049-61-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Altenburger, Jean-Michel; Cremer, Gerard; Lassalle, Gilbert; Matrougui, Mostafa; US2003/207920; (2003); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem