These common heterocyclic compound, 113305-94-5, name is 5-Aminopyrazine-2-carbonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Formula: C5H4N4
To a stirring mixture of 5-aminopyrazine-2-carbonitrile (433 mg, 3.61 mmol) in THF (10 mL) was slowly added sodium hydride (240 mg, 6.02 mmol) below 15 C. The reaction mixture was stirred at room temperature for 1 h. To the above mixture was added compound 305-3 (1.0 g, 3.01 mmol). The resulting mixture was stirred at 60 C for 4 h. The reaction mixture was quenched with ice-water and extracted with ethyl acetate. The organic layer was dried over Na2504 and concentrated to afford the title compound 306-3 (1.5 g, crude) as a yellow oil. LCMS:405.0[M+1].
The synthetic route of 5-Aminopyrazine-2-carbonitrile has been constantly updated, and we look forward to future research findings.
Reference:
Patent; PHARMAENGINE, INC.; CAI, Xiong; QIAN, Changgeng; WANG, Yanong Daniel; (98 pag.)WO2017/132928; (2017); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem