Adding a certain compound to certain chemical reactions, such as: 1458-18-0, name is Methyl 3-amino-5,6-dichloropyrazine-2-carboxylate, belongs to Pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1458-18-0, Safety of Methyl 3-amino-5,6-dichloropyrazine-2-carboxylate
Preparative Example 72. Preparation of Table 1 Compound No. 207; A suspension of 100 (3.6 g, 16 mmol, Aldrich) and sodium hydroxide (1.6 g, 39 mmol) in water (30 ml_) was heated at reflux for 15 min. The solution was filtered, allowed to cool to room temperature, and was acidified with 1 N hydrochloric acid. The precipitated solid 101 (1.2 g, 36% yield) was collected by filtration, air-dried, and dried further under vacuum.
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Reference:
Patent; SCHERING CORPORATION; PHARMACOPEIA DRUG DISCOVERY, INC.; WO2006/88920; (2006); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem