Related Products of 58138-79-7,Some common heterocyclic compound, 58138-79-7, name is 2,6-Diiodopyrazine, molecular formula is C4H2I2N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A mixture of 2,6-diiodopyrazine (1 g, 3.013 mmol), tert-butyl (2S)-2-isobutylpiperazine- 1-carboxylate (949.3 mg, 3.917 mmol) and K2CO3 (624.7 mg, 4.520 mmol) in DMF (5 mL) was heated to 900C and stirred for 17 hrs. It was then allowed to cool and diluted with ethyl acetate and water, further washed organic layer with water and brine, dried (MgSO4) and concentrated to give an orange oil. It was then columned on silica gel eluting with 1 : 1 EtOAc/hexanes to give (S)-tert-buty 4-(6-iodopyrazin-2-yl)-2-isobutylpiperazine-l-carboxylate as a yellow oil 1.05 g, 78%). ES+ 447. IHNMR (CDCl3) 0.98 (6H, d), 1.23 – 1.45 (2H, m), 1.55 – 1.63 (I H, m), 2.91 – 3.00 (I H, m), 3.03 – 3.21 (2H, m), 3.98 – 4.20 (3H, m), 4.25 (I H, brs), 7.95 (I H, s), 8.06 (I H, s).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2,6-Diiodopyrazine, its application will become more common.
Reference:
Patent; VERTEX PHARMACEUTICALS INCORPORATED; JIMENEZ, Juan-Miguel; STUDLEY, John; WO2010/11772; (2010); A2;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem