6863-73-6, name is 3-Chloropyrazin-2-amine, belongs to Pyrazines compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. COA of Formula: C4H4ClN3
3-chloropyrazine-2-amine (1.29 g, 10 mmol)And chloroacetaldehyde (40% aqueous solution, 9.8 g, 50 mmol) were added to 30 mL of isopropanol, and heated under reflux overnight.The solvent was removed by rotary evaporation, and 30 mL of water was added to dissolve.Adjust pH = 7 with saturated sodium bicarbonate solution, extract with ethyl acetate (20mL * 3), combine the organic phases,It was washed with 20 mL of saturated brine, dried over anhydrous sodium sulfate, and concentrated.1.07 g of a pale yellow solid was isolated through a silica gel column with a yield of 70%.
The synthetic route of 6863-73-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Shenzhen Tajirui Bio-pharmaceutical Co., Ltd.; Wang Yihan; Xing Qingfeng; Ai Yixin; (85 pag.)CN110272426; (2019); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem