Adding a certain compound to certain chemical reactions, such as: 14508-49-7, name is 2-Chloropyrazine, belongs to Pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 14508-49-7, COA of Formula: C4H3ClN2
General procedure: A mixture of 2-chloropyrazine (1mmol), 4-ethylphenylboronic acid or 4-methoxy-phenyl boronic acid (1.5mmol), K2CO3 (3mmol), Pd(OAc)2 (0.03mmol), water (2mL) and ethanol (6mL) was stirred at 90C in air for 24h. The reaction mixture was extracted with ethyl acetate, then the combined organic layers were washed with water, dried over MgSO4, filtered, and the solvent was removed on a rotary evaporator. The products were isolated by flash chromatography on silica gel with CH2Cl2 as eluent. The characterization data for 1: Yield: 87%. 1H NMR (400MHz, CDCl3): delta 8.99 (s, 1H), 8.57 (s, 1H), 8.44 (s, 1H), 7.92 (d, J=8.0Hz, 2H), 7.31 (d, J=8.0Hz, 2H), 2.69 (q, J=7.6Hz, 2H), 1.25 (t, J=7.6Hz, 3H). 13C NMR (100MHz, CDCl3): delta 152.8, 146.4, 144.1, 142.6, 142.0, 133.8, 128.6, 126.9, 28.7, 15.4. MS (EI, 70eV) m/z=185.1 (M+H)+. Elemental analysis calcd (%) for C12H12N2: C 78.23, H 6.57, N 15.21. Found: C 78.46, H 6.31, N 15.33. The characterization data for 2, see Supporting Information.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Chloropyrazine, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Xu, Chen; Wang, Zhi-Qiang; Fu, Wei-Jun; Ji, Bao-Ming; Yuan, Xiao-Er; Han, Xin; Xiao, Zhi-Qiang; Hao, Xin-Qi; Song, Mao-Ping; Journal of Organometallic Chemistry; vol. 777; (2015); p. 1 – 5;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem