Reference of 36070-80-1, The chemical industry reduces the impact on the environment during synthesis 36070-80-1, name is 5-Chloropyrazine-2-carboxylic acid, I believe this compound will play a more active role in future production and life.
To a suspension of 5-chloropyrazine-2-carboxylic acid (3.00 g, 18.92 mmol) in Dichloromethane (35 mL) and DMF (0.15 mL) at rt was added oxalyl chloride (2.411 mL, 21.76 mmol) dropwise over 10 mm. The mixture was stirred at rt for 2 h before it was concentrated under vacuum to dryness. The residue was dissolved in dichloromethan (35 mL). dimethylamine in THF (11.83 mL, 23.65 mmol) was was added at rt over 10mm, followed by the addition of triethylamine (5.80 mL, 41.6 mmol). The mixture was stirred at rt for 3 h. The mixture was diluted with ethyl acetate (50 mL) and filtered through Celite. The filtrate was concentrated under vacuum to dryness, and the residue was applied to ISCO (220 g silica gel, solid loading, 70-100% ethyl acetate) to provide the desired product, 5-chloro-N,N-dimethylpyrazine-2-carboxamide (3.18 g, 17.13 mmol,91 % yield), as a white solid.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Chloropyrazine-2-carboxylic acid, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; LIU, Chunjian; LIN, James; MOSLIN, Ryan M.; WEINSTEIN, David S.; TOKARSKI, John S.; WO2015/89143; (2015); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem