136927-64-5, name is 1-Chloropyrrolo[1,2-a]pyrazine, belongs to Pyrazines compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Computed Properties of C7H5ClN2
To a stirred solution of 1-chloro-pyrrolo[1 ,2-a]pyrazine (1.53g, 10 mmol) in THF (90 ml.) was added at 0 C a solution of 1 ,3-dibromo-5,5-dimethylhydantoin (1.49g, 4.9mmol) in THF (10 ml_), via dropping funnel. The funnel was washed with a little THF and this added to the reaction mixture. The reaction mixture was stirred for an hour at 0 C, diluted with DCM and washed with saturated sodium bicarbonate solution. The aqueous layer was back-extracted with DCM. The organic extracts were passed through a hydrophobic frit and evaporated. The residue was purified on silica eluting with 8% EtOAc in iso- hexane to give the title compound as a white solid (1.54 g, 67 %). (0617) [00321] 1 H NMR (CDCI3 ppm) d 7.8 (dd, 1 H, J = 5, 1 Hz), 7.5 (d, 1 H J = 5 Hz ), 7.0 (0618) (dd, 1 H, J = 4, 1 Hz), 6.9 (d 1 H, J = 4Hz). LCMS (m/z) [M+H] 231 , 233
The synthetic route of 136927-64-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; THE UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGH; WALKINSHAW, Malcolm D.; PETTIT, Simon Neil; HIGHTON, Adrian; MCNAE, Iain William; (117 pag.)WO2019/106368; (2019); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem