Sources of common compounds: 957344-74-0

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5,8-Dibromoimidazo[1,2-a]pyrazine, other downstream synthetic routes, hurry up and to see.

Application of 957344-74-0, The chemical industry reduces the impact on the environment during synthesis 957344-74-0, name is 5,8-Dibromoimidazo[1,2-a]pyrazine, I believe this compound will play a more active role in future production and life.

Step 3 (5-Bromoimidazo[l,2-a]pyrazin-8-yl)-(4-(4-methylpiperazin-l-yl)phenylamine[00292] 4-(4-Methylpiperazin-lyl)phenylamine (5 08g, 26 6mmol) and NN- diisopropylethylamine (4 6mL, 26 6mmol) and 5,8-dibromoimidazo[l,2-a]pyrazine (6 Ig, 22 2mmol) in iso-propanol (15OmL), is heated at 900C for 2 days The solvent is removed in vacuo, and the crude residue partitioned between DCM and IN NaOH The organic phase is separated, then washed with water followed by brine. The organic layer is separated, dried (MgSO4) and evaporated. The crude residue is chromatographed on silica gel, eluting with DCM followed by 96:4 DCM NH 3 (7M in MeOH), and the fractions containing the desired product are combined and evaporated The residue is t?turated with Et2theta to afford the title compound as a solid

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5,8-Dibromoimidazo[1,2-a]pyrazine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; GALAPAGOS N.V.; WO2007/131991; (2007); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem