Synthetic Route of 24241-18-7, These common heterocyclic compound, 24241-18-7, name is 2-Amino-3,5-dibromopyrazine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Preparation of intermediate 11-1; A solution of product 2-amino-3,5-dibromo-4-ylpyrazine (cas: 117719-17-2), (40 g, 158 mmol, 1.0 eq) in morpholine (41.5 ml, 474 mmol 3.0 eq) was heated at 120C in a parr reactor for 24h. A brown solid appears. The solid was suspended in DCM and washed with Na2C03 aq. sat (twice). The organic phase was dried (MgS04), filtered and solvent removed in vacuo to give a brown solid, which was triturated from Et20 to afford the desired product (30.54 g, 74%) as a pale brown solid as 11-1.
The synthetic route of 24241-18-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS (CNIO); PASTOR FERNANDEZ, Joaquin; MARTINEZ GONZALEZ, Sonia; ALVAREZ ESCOBAR, Rosa Maria; RODRIGUEZ HERGUETA, Antonio; MARTIN HERNANDO, Jose Ignacio; RAMOS LIMA, Francisco, Javier; WO2011/89400; (2011); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem