Electric Literature of 13301-04-7, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 13301-04-7 as follows.
The compound 3,6-dibromopyrazine-2-carboxylic acid methyl ester 3b (12.0 g, 40.8 mmol) was dissolved in tetrahydrofuran (120 mL). The N2 was replaced 3 times, and the dry ice acetone was cooled to -70 C, DIBAL-H solution (81.6 mL, 122.4 mmol) was added dropwise, and the reaction was carried out at -70 C for 1 hour.The system was quenched by the addition of 1M hydrochloric acid, ethyl acetate was added and stirred for 20 min. Filtration, the filtrate was separated and the aqueous was extracted with ethyl acetate.The organic phase was combined, washed once with saturated brine and dried over anhydrous sodium sulfate, dried under reduced pressure to give the title compound 3c (8.0g, 30.3mmol) using a rotary evaporator, the yield was 74.3 %
According to the analysis of related databases, 13301-04-7, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Shanghai Huahuituo Pharmaceutical Technology Co., Ltd.; Zhejiang Huahai Pharmaceutical Co., Ltd.; Xu Xin; Zhang Tian; Li Yunfei; Wang Guan; Zhu Weibo; Li Qiang; Qu Minkai; Zhang Linli; Song Jinqian; Liu Lei; Chen Haiji; Liu Qiang; Wang Yijin; Ge Jian; (67 pag.)CN109535164; (2019); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem