Adding a certain compound to certain chemical reactions, such as: 2423-65-6, name is Pyrazine 1-oxide, belongs to Pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2423-65-6, Application In Synthesis of Pyrazine 1-oxide
10219] Procedure:10220] Pd(OAc)2 (39.0 mg, 0.17 mmoles), [P(t-13u)3H] HF4 (151 mg, 0.52 mmoles), Pyrazine-i-oxide (1.0 g, 10.4 mmoles), and K2C03 (959 mg, 6.9 mmoles) were added to a dried flask. The flask was fitted with a reflux condenser capped with a septum, evacuated, and purged with nitrogen (.-5 times). A degassed solution of 2-bromopyridine (548 mg, 3.5 mmoles) in dry dioxane (17 mE) was added via syringe, and the reaction was stirred at 1100 C. for 18 hours. The reaction mixture was cooled and filtered through Celite, and the filtrate was concentrated under reduced pressure. The crude product was then purified by chromatography on silica (30% acetone in hexanes) to afford the title compound (312 mg, 52%) as a pale yellow solid. ?H NMR (400 MHz, CDC13) oe 9.35 (s, 1H), 8.75-8.72 (m, 2H), 8.38 (d, J=4.0 Hz, 1H), 8.15 (dd, J=0.4, 4.0 Hz, 1H), 7.81 (ddd, J=i.6, 2.0, 8.0 Hz, 1H), 7.25 (ddd, J=0.8, 4.8, 8.0 Hz, 1H); ?3C NMR (100 MHz, CDC13) oe 149.9, 149.7, 147.3,145.8, 142.2, 136.5, 134.5, 125.4, 124.8; HRMS (ESI) mlz174.0662 [calc?d for C9H8N30 (M+H) 174.0662].
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Pyrazine 1-oxide, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; WISCONSIN ALUMNI RESEARCH FOUNDATION; RAINES, Ronald T.; Vasta, James; (50 pag.)US2016/280701; (2016); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem