Electric Literature of 1111638-10-8, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1111638-10-8 as follows.
To a stirring solution of product of step 2 (20 mg, 0.130 mmol) in acetic acid (1 ml) and water (2.0 ml) was added Hexamethylenetetramine (20.08 mg, 0.143 mmol) and the reaction mixture was heated for 5 h at l20C. After completion of reaction it was diluted with ethyl acetate (10 ml) and 10 ml of water. Organic layer was separated, dried over Na2S04 and evaporated to get desired product. ESI-MS (m/z): 180.00 (M-H).
According to the analysis of related databases, 1111638-10-8, the application of this compound in the production field has become more and more popular.
Reference:
Patent; CADILA HEALTHCARE LIMITED; DESAI, Ranjit; PANDYA, Vrajesh; PUJARA, Mehul; ARGADE, Anil; JOSHI, Jignesh; SATYANAND, Anshul; (66 pag.)WO2019/239382; (2019); A1;,
Pyrazine – Wikipedia,
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