Reference of 1422772-78-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1422772-78-8 name is 2-Bromo-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Step 22-Bromo-5H-pyrrolo[2,3-b razine-7-carboxylic acid methyl esterTo a stirred solution of 2-bromo-5H-pyrrolo [2,3-b]pyrazine-7-carboxylic acid (0.527 g, 2.18 mmol) in 50 mL of methanol was added H2SO4 (1.5 mL) slowly at room temperature. The reaction mixture was stirred at reflux for 16 h. The solvent was evaporated at 40C under reduced pressure then the residue was suspended in 5 mL of water and treated with solidNaHC03 until pH = 7. The solution was extracted with ethyl acetate (90 mL), then the organics were washed with water (20 mL), brine (20 mL) and dried over anhydrous sodium sulfate. The drying agent was removed by filtration and the solvent was evaporated at 40C under reduced pressure to give a crude product, which was purified by column chromatography (silica gel, 200 – 300 mesh, eluting with a mixture of petroleum ether and ethyl acetate (1 :1 , v/v) to give 2- bromo-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid methyl ester (0.24 g, 43 %) as a white solid. LCMS: (M+H)+ = 278; 1H NMR (300 MHz, DMSO-d6): ? 8.62 (s, 1H), 8.48 (s, 1H), 3.91 (s,3H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Bromo-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid, and friends who are interested can also refer to it.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; CHEN, Shaoqing; DE VICENTE FIDALGO, Javier; HAMILTON, Matthew Michael; HERMANN, Johannes Cornelius; KENNEDY-SMITH, Joshua; LI, Hongju; LOVEY, Allen John; LUCAS, Matthew C.; LUK, Kin-Chun Thomas; LYNCH, Stephen M.; O’YANG, Counde; PADILLA, Fernando; SCHOENFELD, Ryan Craig; SIDDURI, Achyutharao; SOTH, Michael; WANG, Ce; WOVKULICH, Peter Michael; ZHANG, Xiaohu; WO2013/30138; (2013); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem