Adding a certain compound to certain chemical reactions, such as: 19745-07-4, name is 2,5-Dichloropyrazine, belongs to Pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 19745-07-4, Computed Properties of C4H2Cl2N2
General procedure: m-DCzP, o-DCzP were synthesized by nucleophilic reaction without heavy metal catalysts. Carbazole (0.34 g,2 mmol), dichloropyrazine (0.148 g, 1 mmol), and K2CO3 (1.136 g, 8 mmol) were mixed in dimethyl sulfoxide (DMSO, 5ml), then the mixture was stirred at 150C for 4 h under a nitrogen atmosphere. After cooling to room temperature, the mixture was poured into water, stirred, and filtered. The residue was dried in vacuum drying over at 60C for 4 h, and thenpurified by column chromatography over silica gel with CH2Cl2/petroleum ether as the eluent to afford a yellow/white solid. To further purify the products, CH2Cl2/ethyl acetate was used as solvents for recrystallization resulting in pure single crystals of p-DCzP, m-DCzP and o-DCzP. They were obtained with high yields (75%) except for o-DCzP which was obtained with only 50% yield.
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Reference:
Article; Zhang, Yanni; Zhao, Jianfeng; Zhu, Caixia; Bian, Lifang; Shi, Huifang; Zhang, Shiming; Ma, Huili; Huang, Wei; Chinese Chemical Letters; vol. 30; 11; (2019); p. 1974 – 1978;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem