33332-29-5, name is 2-Amino-5-chloropyrazine, belongs to Pyrazines compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Quality Control of 2-Amino-5-chloropyrazine
17 (1.1 g, 8.5 mmol) was dissolved in dichloromethane (25 mL) followed by the addition of NBS (1.52 g, 8.5 mmol) in batches over a period of 15 min at room temperature. When the reaction was completed, saturated aqueous Na2CO3 solution (10 mL) was added. After stirring for 10 min, the mixture was partitioned between dichloromethane (100 mL) and water (100 mL). The organic layer was dried over anhydrous Na2SO4, decolorized with activated charcoal (0.5 g), and concentrated to give a yellow solid (1.53 g, yield 87%). 2-Amino-3-bromo-5-chloropyrazine (18a) Yield: 87%, yellow solid, M.p.: 108-110 C. 1H NMR(400 MHz, CDCl3): delta 7.97 (s, 1H), 5.08 (s, 2H). 1H NMR(400 MHz, DMSO-d6): delta 8.10 (s, 1H), 6.99 (s, 2H). 13CNMR (125 MHz, CDCl3):delta 151.66, 140.26, 134.75, 123.27. EI-MS m/z: 207 (M+, Cl35, Br79,76), 209 (M+, Cl37,Br79 and Cl35,Br81,100), 211 (M+, Cl37, Br 81,26), 128 (M+,Cl35,-Br, 75), 130 (M+, Cl37,-Br, 25), 101 (M+, Cl35,-Br,-HCN, 30), 103 (M+, Cl37,-Br, -HCN, 10).
The synthetic route of 33332-29-5 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Guo, Qi; Xu, Mingshuo; Guo, Shuang; Zhu, Fuqiang; Xie, Yuanchao; Shen, Jingshan; Chemical Papers; vol. 73; 5; (2019); p. 1043 – 1051;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem