Related Products of 143591-61-1, These common heterocyclic compound, 143591-61-1, name is 3-Bromo-8-chloroimidazo[1,2-a]pyrazine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
3-Bromo-jV-isopropylimidazor 1 ,2-a1pyrazin-8-amine[00276] A neat mixture of 3-bromo-8-bromo/chloroimidazo[l,2-a]pyrazine (200 mg, 0.86 mmol) and isopropylamine (20 equivalents, 1.48 mL, 17.2 mmol) was stirred at 17O0C for 16hr in a sealed tube. After cooling down, the resulting mixture was partitioned between DCM (150 mL) and water (100 mL). The two layers were separated and the aqueous layer was extracted further with DCM (2 x 50 mL). The combined organic extracts were washed with brine until and dried over anhydrous MgSO4. Evaporation of the solvent afforded crude product (204 mg, 93%). LCMS RT = 1.23 min, MH+ 255.1 & 257.1. 1U NMR (CDCl3): 7.40-7.36 (2H, m), 7.30 (IH, d, J4.8), 5.72 (IH, br s), 4.42-4.22 (IH, br m), 1.27 (3H, s), 1.25 (3H, s).
Statistics shows that 3-Bromo-8-chloroimidazo[1,2-a]pyrazine is playing an increasingly important role. we look forward to future research findings about 143591-61-1.
Reference:
Patent; BioMarin IGA, Ltd.; WREN, Stephen Paul; WYNNE, Graham Michael; LECCI, Cristina; WILSON, Francis Xavier; PRICE, Paul Damien; MIDDLETON, Penny; WO2010/69684; (2010); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem