Application of 889447-19-2, These common heterocyclic compound, 889447-19-2, name is 2-Chloro-5H-pyrrolo[2,3-b]pyrazine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Example 33A 2-chloro-7-iodo-5H-pyrrolo[2,3-b]pyrazine A 1 M solution of iodine monochloride in dichloromethane (9.84 mL, 9.84 mmol) was added dropwise to an ice-cold solution of 2-chloro-5H-pyrrolo[2,3-b]pyrazine (6.75 g, 11.07 mmol) in anhydrous pyridine (12 mL). The reaction mixture was stirred at 0 C. for 60 minutes, then concentrated. The residue was partitioned between ethyl acetate and brine. The organic phase was washed with brine and concentrated. The crude product was stirred with 15 mL of dichloromethane. The yellow solid material was collected by filtration, washed with dichloromethane and dried to give 2.86 g of the title product. Yield: 66%. MS (DCI+) m/z 280 (M+H)+.
Statistics shows that 2-Chloro-5H-pyrrolo[2,3-b]pyrazine is playing an increasingly important role. we look forward to future research findings about 889447-19-2.
Reference:
Patent; ABBOTT LABORATORIES; US2011/15172; (2011); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem