New learning discoveries about 25710-18-3

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2,3-Dichloropyrido[2,3-b]pyrazine, its application will become more common.

Application of 25710-18-3,Some common heterocyclic compound, 25710-18-3, name is 2,3-Dichloropyrido[2,3-b]pyrazine, molecular formula is C7H3Cl2N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A suspension of 2,3-dichloro-pyrido[2,3-b]pyrazine (200mg; lmmol; leq), ethane sulfonamide (109.1 mg, 1 mmol, 1 eq.), 7-methyl-l,5,7-triazabicyclo[4.4.0]dec-5-ene on polystyrene. hi (862 mg, 2.5 mmol, 2.5 eq.) and NaI (149.87 mg, lmmol, 1 eq.) in DMA (5 ml) is heated at 1000C in the microwave for 1 hour under high absorbance. HCl in dioxane (374.9 mul, 4M; 1.5 mmol, 1.5 eq.) then 3,5-dimethoxyaniline (765.8 mg, 5 mmol, 5 eq.) are added, and the resulting reaction mixture is heated at 1700C in the microwave for 30 min. The polymer is filtered off, washed with DMA, and the solvent evaporated under reduced pressure. The product was extracted withEtOAc, the organic layer is washed with brine and dried under MgSO4 them conecentrated to near dryness. The residue is purified by preparative HPLC to afford 69.4 mg (18 percent) of the title EPO compound as a parent. The parent (58.6 mg, 0.15 mmol, 1 eq.) is suspended in water (2 ml) then potassium hydroxide (300.9 mul, 0.50 M, 0.15 mmol, 1 eq.) is added and the mixture is lyophilised to afford 64 mg (99 percent) of the title compound as a yellow powder. IH NMR (DMSO- d6) delta 8.92 (s, IH), 8.34 (dd, J = 4.5, 1.7 Hz, IH), 7.79 (dd, J = 7.9, 1.7 Hz, IH), 7.31 (d, J = 2.3 Hz, 2H), 7.14 (dd, J = 7.9, 4.5 Hz, IH), 6.16 (t, J = 2.3 Hz, IH), 3.78 (s, 6H), 3.40 (q, J = 7.5 Hz, 2H), 1.15 (t, J = 7.5 Hz, 3H). HPLC (max plot) 99percent; Rt 2.87 min. LC/MS: (ES+): 390.3, (ES-): 388.3.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2,3-Dichloropyrido[2,3-b]pyrazine, its application will become more common.

Reference:
Patent; APPLIED RESEARCH SYSTEMS ARS HOLDING N.V.; WO2007/23186; (2007); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem