Synthetic Route of 63744-22-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 63744-22-9, name is 6,8-Dibromoimidazo[1,2-a]pyrazine belongs to Pyrazines compound, it is a common compound, a new synthetic route is introduced below.
6 8-dibromo-3-iodo-imidazo[1 ,2-a]pyrazineTo a stirred solution of 8.7 g (31.4 mmol) 6,8-dibromo-imidazo[1 ,2-a]pyrazine which was prepared according to a procedure described in the Journal of Medicinal Chemistry, 1984, vol. 27, No. 2, p. 206 – 212 in 210 ml_Nu,Nu-dimethylformamide was added 7.42 g N-iodopyrrolidin-2,5-dione in one portion at 23 C. After 18 hours of stirring at 60 C, the solvent was removed in vaccuo and the residue was taken up in dichloromethane and washed with water and saturated sodium thiosulfate solution. The organic phase was dried over sodium sulphate, filtered and the solvent was evaporated to yield 9.46 g (74.8 of the title compound.
The synthetic route of 6,8-Dibromoimidazo[1,2-a]pyrazine has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; KLAR, Ulrich; KOPPITZ, Marcus; JAUTELAT, Rolf; KOSEMUND, Dirk; BOHLMANN, Rolf; BADER, Benjamin; LIENAU, Philip; SIEMEISTER, Gerhard; SCOTT, William; WO2011/151259; (2011); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem