Reference of 19745-07-4, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 19745-07-4, name is 2,5-Dichloropyrazine, This compound has unique chemical properties. The synthetic route is as follows.
Example 745-[(5-Ch[oropyrazin-2-y[)amino]-N- (3,4-dif[uoropheny[)-3-methy[- 1 ,2-thiazo[e-4- carboxamideA mixture of 5-amino-N-(3,4-dif[uoropheny[)-3-methy[-1 ,2-thiazo[e-4-carboxamide [Intermediate 3] (300 mg, 1.11 mmo[, 1.0 eq), 2,5-dich[oropyrazine [CAS RN:19745-07-4] (166 mg, 1.11 mmo[, 1.0 eq) and cesium carbonate (835 mg,2.56 mmo[, 2.3 eq) in 11 mL dioxane/DMF (7/1) was p[aced in a microwave via[ and f[ushed with argon. Then, pa[[adium(II) acetate (25 mg, 0.11 mmo[, 0.1 eq) andXantphos (64 mg, 0.11 mmo[, 0.1 eq) were added. The via[ was capped and the reaction mixture was stirred at an environmenta[ temperature of 110 ¡ãC overnight. On coo[ing, the reaction mixture was partitioned between dich[oromethane/methano[ (5/1) and water. The organic phase was washed with brine and the phases were separated by the use of a Whatman fi[ter. The crude materia[ wascrysta[[ized with dich[oromethane/methano[ and the preciptitate was iso[ated via fi[tration. After drying, 192 mg (6 percent yie[d of theory) of the tit[e compound were obtained.UPLC-MS (Method 3): Rt = 1 .29 mm; MS (ESIneg) m/z = 380 [M-H].1HNMR (400 MHz, DMSO-d6): oe [ppm] = 2.44 (s, 3H), 7.38-7.53 (m, 2H), 7.94 (dd,1H), 8.56 (s, 2H), 10.47 (s br, 1H), 11.10 (s br, 1H).
The chemical industry reduces the impact on the environment during synthesis 2,5-Dichloropyrazine. I believe this compound will play a more active role in future production and life.
Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; BAeRFACKER, Lars; PRECHTL, Stefan; SIEMEISTER, Gerhard; WENGNER, Antje Margret; ACKERSTAFF, Jens; NOWAK-REPPEL, Katrin; BADER, Benjamin; LIENAU, Philip; STOeCKIGT, Detlef; WO2014/118186; (2014); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem