In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1320266-92-9 as follows. category: Pyrazines
l-iodo-3-isopropyl-N-methylimidazo[l,5-a]pyrazin-8-amine (compound 6). Compound 5 (21.8 mg, 0.068 mmol) was dissolved in a solution of 40% MeNH2 in MeOH (91 muEpsilon) and was stirred at 80 oC for 2 h in a microwave. The reaction mixture was concentrated in vacuo to obtain 20.3 mg of compound 6 (94% yield). TLC (hexanes:EtOAc, 50:50 v/v): Rf = 0.2; 1H NMR 1H NMR (300 MHz, MeOD) delta 7.51 (d, J = 6.0 Hz, 1H), 7.04 (d, J = 6.0 Hz, 1H), 3.42 – 3.34 (m, 1H), 3.07 (s, 3H), 1.37 (d, J = 6.0 Hz, 6H); ESI-MS (m/z): [M]+ calcd. for CI OH 13GammaNu4, 316.02; [M+l]+ found, 317.1.
According to the analysis of related databases, 1320266-92-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; MALY, Dustin J.; BACKES, Bradley, J.; OAKES, Scott, A.; PAPA, Feroz, R.; GHOSH, Rajarshi; WANG, Likun; (220 pag.)WO2016/4254; (2016); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem