Related Products of 186534-02-1,Some common heterocyclic compound, 186534-02-1, name is 3,5,6-Trimethylpyrazine-2-carbaldehyde, molecular formula is C8H10N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Example 1 Synthesis of TBN (FIG. 2) 2-[[(1,1-Dimethylethyl)oxidoimino]methyl]-3,5,6-trimethylpyrazine (TBN). To aldehyde 5 (1.9 g, 0.013 mol) in methanol (200 mL) was added tert-butylhydroxylamine (1 g, 0.011 mol), and the solution was refluxed for 2 h. Another portion of tert-butyl hydroxylamine (1 g, 0.011 mol) was then added, and the solution refluxed until aldehyde 5 was completely reacted. Solvent was removed in vacuo, and the product was extracted. The solution was dried with Na2SO4, and solvent removed in vacuo. The product was purified by column chromatography, eluding with ethyl acetate/petroleum ether (1/1, v/v), to produce TBN as a light yellow solid (1.1 g, 38% yield), mp: 68-70 C. 1H NMR (CDCl3, ppm): 7.82 (s, 1H), 2.47 (s, 3H), 2.50 (s, 3H), 2.52 (s, 3H), 1.63 (s, 9H). ESI-MS: 222 [M+H]+, 244 [M+Na]+. Anal. (C12H19N3O) C, H, N.
The synthetic route of 186534-02-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Wang, Yuqiang; Jiang, Jie; Yu, Pei; Sun, Yewei; Wang, Linda; Zhang, Zaijun; US2011/34485; (2011); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem