Adding a certain compound to certain chemical reactions, such as: 136927-64-5, name is 1-Chloropyrrolo[1,2-a]pyrazine, belongs to Pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 136927-64-5, Computed Properties of C7H5ClN2
Compound C4 (63.0 mg, 0.294 mmol), 1-chloropyrrolo[1,2-a]pyrazine (32.5 mg,0.21 mmol), and cesium carbonate (208 mg, 0.64 mmol) were combined in dimethylsulfoxide (1.0 mL), and the mixture was degassed with nitrogen for 5 minutes. After the reaction mixture had been heated to 120 C for 72 hours, it was cooled to room temperature, diluted with ethyl acetate, and filtered through diatomaceous earth. The filter pad was rinsed with ethyl acetate, and the combined filtrates were washed with 1:1water I saturated aqueous sodium chloride solution, dried over sodium sulfate, filtered,and concentrated in vacuo. Purification using silica gel chromatography (Gradient: 0%to 5% methanol in dichloromethane) afforded the product as a white solid. Yield: 34 mg,0.10 mmol, 48%. LCMS m/z 331.1 [M+H]. 1H NMR (400 MHz, CDCI3) oe 9.00 (5, 1H),7.62 (d, J=4.8 Hz, 1H), 7.47-7.45 (m, 1H), 7.28-7.22 (m, 2H), 7.11-7.09 (m, 2H), 6.99-6.98 (m, 1H), 6.86-6.85 (m, 1H), 2.29 (5, 6H), 2.05 (5, 3H).
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Reference:
Patent; PFIZER INC.; GRAY, David Lawrence Firman; DAVOREN, Jennifer Elizabeth; DOUNAY, Amy Beth; EFREMOV, Ivan Viktorovich; MENTE, Scot Richard; SUBRAMANYAM, Chakrapani; WO2015/166370; (2015); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem