Related Products of 25710-18-3, These common heterocyclic compound, 25710-18-3, name is 2,3-Dichloropyrido[2,3-b]pyrazine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
[0450] Example 15 [0451 ] Synthesis of 3 -(4-(2,5 -dichlorobenzyl)piperazin- 1 -yl)-N-(pyridin-3 -yl)pyrido [2,3 – b]pyrazin-2-amine, 2,2,2-trifluoroacetic acid salt [0452] Step 1 : 2-chloro-3-(4-(2,5-dichlorobenzyl)piperazin-l-yl)pyrido[2,3-b]pyrazine [0453] To a solution of 2,3-dichloropyrido[2,3-b]pyrazine (21 mg, 0.105 mmol) and l-(2,5- dichlorobenzyl)piperazine, HC1 (31.0 mg, 0.1 10 mmol) in dioxane (350 mu) was added N- ethyl-N-isopropylpropan-2-amine (56.8 mu, 0.325 mmol) dropwise at RT. The resulting mixture was stirred at RT overnight and HPLC purification yielded the title compound as a yellow solid.
The synthetic route of 25710-18-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ENVOY THERAPEUTICS, INC.; HITCHCOCK, Stephen; MONENSCHEIN, Holger; REICHARD, Holly; SUN, Huikai; KIKUCHI, Shota; MACKLIN, Todd; HOPKINS, Maria; WO2014/28479; (2014); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem