Related Products of 23688-89-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 23688-89-3 as follows.
Intermediate 13 was prepared from the indicated bromide and boronic acid by methods analogous to those described for Intermediate 12.:_To a solution of ethyl 2-ethoxy-4-(4,4, 5, 5-tetramethyl- 1, 3,2-dioxaborolan-2- yl)benzoate (439 mg, 1.37 mmol) and 6-bromo-5-fluoropicolinic acid (302 mg, 1.37 mmol) in 1,4-dioxane (6.9 ml) was added a solution of sodium carbonate (436 mg, 4.11 mmol) in water (2 ml). The reaction was purged with nitrogen and PdCI2(dppf)-CH2CI2 adduct (112 mg, 0.14 mmol) was added and the reaction then heated at 80 00 for 18 hours. The reactionwas then cooled to room temperature and concentrated. The residue was partitioned between water and EtOAc and the aqueous phase acidified. The layers were separated, and the aqueous phase was extracted with further EtOAc (3 x 20 ml). The combined organic extracts were dried over Mg504, filtered, and concentrated to give the title compound as an orange solid (129 mg, 28 % yield).
According to the analysis of related databases, 23688-89-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED; DOWDELL, Sarah E.; EIDAM, Hilary Schenck; ELBAN, Mark; FOX, Ryan Michael; HILFIKER, Mark A.; HOANG, Tram H.; KALLANDER, Lara S.; LAWHORN, Brian Griffin; MANNS, Sharada; PHILP, Joanne; WASHBURN, David G.; YE, Guosen; (274 pag.)WO2017/6295; (2017); A1;,
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