Adding a certain compound to certain chemical reactions, such as: 56423-63-3, name is 2-Bromopyrazine, belongs to Pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 56423-63-3, Formula: C4H3BrN2
General procedure: These compounds were synthesized according to previously reported method.3 Under nitrogen atmosphere, to a mixture of 25 (3.0 mmol), K2CO3 (4.5 mmol) and CuI (0.3 mmol) in DMA (10 mL) was added 24a-24c (3.0 mmol). The reaction flask was heated to 90 C and stirred for 36-48 h. After being cooled to rt, the reaction mixture was diluted with ethyl acetate and water. Under cooling with ice/water, concentrated HCl was added to adjust the pH to 3. The organic phase was separated, and the aqueous phase was extracted with ethyl acetate. The combined organic phase was washed with brine, dried over anhydrous Na2SO4, and the solvent was removed under reduced pressure. The crude product was purified by silica gel column chromatography to yield the desired compounds 26a-26c.
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Reference:
Article; Xu, Yulong; Yang, Xicheng; Chen, Yiyi; Chen, Hao; Sun, Huijiao; Li, Wei; Xie, Qiong; Yu, Linqian; Shao, Liming; Bioorganic and Medicinal Chemistry Letters; vol. 28; 12; (2018); p. 2148 – 2152;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem