Some common heterocyclic compound, 14667-55-1, name is 2,3,5-Trimethylpyrazine, molecular formula is C7H10N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C7H10N2
Example 10 [00650] Preparation of Cpd 76 [00651] The bromoketone intermediate obtained in Step C, Example 6 (855 mg, 3.0 mmol) was mixed with 2,3,5-trimethylpyrazine (402 mg, 3.3 mmol) and acetonitrile (10.0 mL) in a sealed tube. The mixture was stirred at 80 C for 4 hr and cooled to room temperature, followed by the addition of triethylamine (1.3 mL, 9.0 mmol). After stirring for 0.5 hours at room temperature, the mixture was stirred at 60 C overnight. The solvent was removed on a rotovap and the residue was chromatographed (silica gel, ethylacetate in dichloromethane 30%) to provide the intermediate, 3-(l,3-dimethylpyrrolo[l,2-a]pyrazin-7-yl)-7-fluoro-lH-isochromen-l- one (782 mg, 85%). MS m/z 309.3 [M+H]+.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 14667-55-1, its application will become more common.
Reference:
Patent; PTC THERAPEUTICS, INC.; CHEN, Guangming; DAKKA, Amal; KARP, Gary Mitchell; LI, Chunshi; NARASIMHAN, Jana; NARYSHKIN, Nikolai; WEETALL, Maria L.; WELCH, Ellen; ZHAO, Xin; WO2013/112788; (2013); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem