Electric Literature of 32587-10-3, A common heterocyclic compound, 32587-10-3, name is 3-Aminopyrazine-2-carboxamide, molecular formula is C5H6N4O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
(d) In 5 mL of trifluoroacetic acid was dissolved 100 mg of 3-amino-2-pyrazinecarboxamide. At an ice-cooled temperature, 10% fluorine gas (a fluorine gas diluted with nitrogen gas) was introduced at a rate of 45 mL per minute for a period of 36 minutes. Then, while elevating the temperature from the ice-cooled temperature to room temperature, nitrogen gas was introduced for one hour. The reaction mixture was concentrated under reduced pressure to obtain 305 mg of an oily product. Of the oily product thus obtained, a 251 mg portion was dissolved in 9.3 mL of water and heated under reflux for 4 hours, The liquid reaction mixture was cooled to room temperature, and the deposited precipitate was filtered off. The filtrate was concentrated under reduced pressure, and the solid product thus obtained was purified by silica gel column chromatography [eluent: n-hexane:ethyl acetate=2:1] to obtain 9 mg of 3-amino-6-fluoro-2-pyrazinecarboxamide as a solid product.
The synthetic route of 32587-10-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Toyama Chemical Co., Ltd.; US2003/130213; (2003); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem