Synthetic Route of 63286-28-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 63286-28-2 name is 2-Chloro-3-hydrazinylpyrazine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Intermediate B-1 (15.0 g; 104 mmol) is suspended in toluene (135 mL) at ambient temperature. Acetic anhydride (11.1 g; 109 mmol) dissolved in 7.5 mL toluene is slowly added to the suspension. The reaction mixture is stirred at ambient temperature for 2.5 h. The product is isolated by filtration. Yield: 99 % (19.2 g, 103 mmol) ESI-MS: (M+H)+ = 187/189
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Chloro-3-hydrazinylpyrazine, and friends who are interested can also refer to it.
Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; TONTSCH-GRUNT, Ulrike; BAUM, Anke; RUDOLPH, Dorothea Ingrid; (85 pag.)WO2019/145410; (2019); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem