173290-17-0, name is Methyl 3-iodopyrazine-2-carboxylate, belongs to Pyrazines compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. HPLC of Formula: C6H5IN2O2
Example 5 Preparation of Methyl 3-trifluoromethyl-pyrazine-2-carboxylate (8) To methyl 3-iodopyrazine-2-carboxylate (7) (10 g, 37.88 mmol) in DMF (Volume: 300 mL) was added methyl chlorodifluoroacetate (27 g, 0.189 mol), potassium fluoride (13.2 g, 0.227 mol), and copper chloride (22.47 g., 0.227 mol). The reaction was heated at 120 C. for 12 h. The reaction mixture was poured into ethyl ether (1000 ml) and washed with brine (3*300 ml), dried over MgSO4 before the solvent was removed. The residue was loaded onto a silica column and was eluted using ethyl acetate/hexanes gradient to afford the title compound (3.19 g, 41%) as an amber oil: 1H NMR (400 MHz, CDCl3) delta 8.85 (d, J=5.4 Hz, 1H), 8.82 (d, J=5.4 Hz, 1H), 4.05 (s, 3H); EIMS m/z 206.
The synthetic route of 173290-17-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; DOW AGROSCIENCES LLC; US2011/301178; (2011); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem