In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 36070-75-4 as follows. Quality Control of 5-Chloropyrazine-2-carbonitrile
To a microwave vial 5-chloropyrazine-2-carbonitrile (74.1 mg, 0.531 mmol), rac-(2S,3R,4R)-1-acetyl-4-amino-2-cyclopropyl-N,3-dimethyl- 1,2 ,3,4-tetrahydroqu inoline-6-carboxamide (for preparation seeIntermediate 200, 80 mg, 0.265 mmol), and DIPEA (0.139 mL, 0.796 mmol) were added and thereaction irradiated at 200 C in a microwave for 30 mins. The reaction was purified directly usingMDAP (Formic) to give a beige solid. This solid was eluted through a NH2 SPE (5 g) with MeOH, theeluent was concentrated to the product (63 mg, 0.156 mmol, 58.7%) as a beige solid.LCMS (2 mm Formic): Rt = 0.78 mi [MH] = 405.
According to the analysis of related databases, 36070-75-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED; AMANS, Dominique; ATKINSON, Stephen John; HARRISON, Lee Andrew; HIRST, David Jonathan; LAW, Robert Peter; LINDON, Matthew; PRESTON, Alexander; SEAL, Jonathan Thomas; WELLAWAY, Christopher Roland; WO2014/140076; (2014); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem